At a glance
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Effects of Magnesium Sulphate on Sugammadex Reversal of Rocuronium Induced Blockade in Gynaecology Patients
In Brief
A Phase 4 clinical trial evaluating placebo, Magnesium Sulphate, and 1 other intervention for Pre-eclampsia Aggravated. Completed, enrolled 80 participants across 1 site.
Detailed Summary
Background: The aim of this prospective study was to evaluate the effect of magnesium on the reversal of rocuronium-induced neuromuscular block by sugammadex. Methods: Eighty patients, aged 18 to 60 years, American Society of Anesthesiologists I-II, undergoing elective gynecological surgery were enrolled. Anaesthesia was induced with propofol and fentanyl and was maintained with 60% nitrous oxide and Oxygen in sevoflurane. The magnesium group received 50 milligram/kilogram (mg/kg) Magnesium intravenous (iv) as a bolus and 15 mg/kg/hour by continuous infusion until the completion of surgery. The placebo group received the equivalent volume of isotonic saline. For intubation, 0.6 mg/kg rocuronium was administered and 0.1 mg/kg was added when Train of four (TOF) counts reached 1 or more during the procedure. At the end of the surgery at a TOF count of 1, 4 mg/kg sugammadex iv was administered. Patients were observed until a TOF ratio of 0.9 was achieved. Patient-controlled analgesia with intravenous morphine was used postoperatively.
Study Details
Timeline
Interventions
Active comparator 50 mg/kg iv bolus plus 15 mg/kg continuous infusion
Experimental : 50 mg/kg bolus plus 15 mg/kg continuous infusion
4 mg/kg iv bolus at the end of the surgery