At a glance
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Measurement of Retinal Auto Fluorescence With a Fluorescence Lifetime Imaging Ophthalmoscope
In Brief
An observational study evaluating Fluorescence lifetime ophthalmoscope for Autofluorescence Imaging and Neuroimaging. Completed, enrolled 892 participants across 1 site.
Detailed Summary
Fluorescent lifetime microscopy has emerged as a useful tool to study fluorescent lifetimes in vitro. Fluorescence lifetime represents the average amount of time a fluorophore remains in the excited state following excitation and depends on the fluorophores molecular environment. Fluorescence lifetime ophthalmoscopy (FLIO) is a technique which can quantify fluorescence lifetimes in the human retina in vivo. The purpose of this study is to investigate fluorescence lifetime characteristics in the human retina by using a FLIO. The investigators hypothesize that FLIO will allow to identify areas of retinal metabolic stress such as ischemia by detecting changes in fluorescence lifetimes.
Study Details
Timeline
Interventions
All patients and healthy subjects will be imaged with the fluorescence lifetime ophthalmoscope