At a glance
ClinicalIndex Comparison RecordPhase 2Completed· 66 enrolled
Drug / intervention
Thiaminedrug
Likely dose
Thiamine 200 mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
The Effect of Thiamine vs. Placebo on VO2 in Critical Illness
In Brief
A Phase 2 clinical trial evaluating Thiamine for Critically Ill and Respiratory Failure. Completed, enrolled 66 participants across 1 site.
Detailed Summary
The objective of this study is to determine the effect of thiamine therapy on oxygen consumption (VO2) in critically-ill patients. We will evaluate this by measuring VO2 before and after thiamine or placebo administration in patients admitted to the ICU and requiring mechanical ventilation. A secondary aim is to evaluate the effect of thiamine vs. placebo on the metabolic profile of the patients.
Study Details
Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsCritically Ill, Respiratory Failure
CountriesUnited States
Collaborators--
Timeline
Phase 2CompletedFinished
2014201520162017201820192020202120222023202420252026
Enrollment StartOct 2013
First PostedNov 2013
Primary CompletionMay 2016
Study CompletionDec 2016
TodayJul 2026
First PostedNov 15, 2013
Enrollment StartOct 1, 2013
Primary CompletionMay 1, 2016
Study CompletionDec 1, 2016
TodayJul 2, 2026
Enrollment to primary: 2.6 yearsPosted 12.6 years ago
Interventions
Thiaminedrug
200 mg IV thiamine