CI

At a glance

ClinicalIndex Comparison Record
Phase 3Completed· 82 enrolled
Drug / intervention
Ticagrelor mashed pills +1 moredrug
Likely dose
Ticagrelor mashed pills 90 mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT01992523
NCT01992523Phase 3Completed
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Mojito Study (Mashed Or Just Integral Pill of TicagrelOr ? )

David Antoniucci·interventional·Posted Nov 25, 2013·Updated Mar 17, 2015

In Brief

A Phase 3 clinical trial evaluating Ticagrelor mashed pills and Ticagrelor integral pills for Acute Coronary Syndrome and Adverse Reaction to Antiplatelet Agent. Completed, enrolled 82 participants across 2 sites in 2 countries.

Detailed Summary

The aim of the Mashed Or Just Integral pill of TicagrelOr (MOJITO) study is to evaluate the superiority of Ticagrelor 180 mg LD mashed pill versus Ticagrelor 180 mg LD integral pill both orally administrated in decreasing residual platelet reactivity 1 hour after the administration among 70 patients with STEMI (ST segment elevation myocardial infarction) undergoing PPCI (primary percutaneous coronary intervention) with bivalirudin monotherapy.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsAcute Coronary Syndrome, Adverse Reaction to Antiplatelet Agent
CountriesGreece, Italy
CollaboratorsAstraZeneca, A.R. CARD Onlus Foundation

Timeline

Phase 3CompletedFinished
2014201520162017201820192020202120222023202420252026
First PostedNov 25, 2013
Enrollment StartNov 1, 2013
Primary CompletionMar 1, 2014
Study CompletionApr 1, 2014
TodayJul 2, 2026
Enrollment to primary: 4 monthsPosted 12.6 years ago

Interventions

Ticagrelor mashed pillsdrug

The loading dose will be performed as soon as possible in the Emergency Room or in the Cath Lab. In all case before the end of the PCI (percutaneous coronary intervention) . In the case of vomit in the first hour after drug loading dose a new reduced loading dose will be administered (90 mg Ticagrelor). Mashed pills administration will be prepared placing 2 ticagrelor pills in a mortar and mashing for 60 seconds using a pestle. The total contents of the mortar will be transferred to the dosing cup, 50 mL of purify water will be added, and the suspension mixed up before drinking. Afterwards, 100 mL of purify water will be administered to the patient.

Ticagrelor integral pillsdrug

The loading dose will be performed as soon as possible in the Emergency Room or in the Cath Lab. In all case before the end of the PCI (percutaneous coronary intervention) . In the case of vomit in the first hour after drug loading dose a new reduced loading dose will be administered (90 mg Ticagrelor).