CI

At a glance

ClinicalIndex Comparison Record
Phase 4Completed· 191 enrolled
Drug / intervention
Total intravenous anesthesia with propofol +1 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT01993836
NCT01993836Phase 4Completed
CompareCT.gov

Markers of Alzheimers Disease and Cognitive Outcomes After Perioperative Care

Duke University·interventional·Posted Nov 25, 2013·Updated Mar 22, 2023

In Brief

A Phase 4 clinical trial evaluating Total intravenous anesthesia with propofol and General anesthesia with isoflurane for Alzheimers Disease and 2 related conditions. Completed, enrolled 191 participants across 1 site.

Detailed Summary

This study will examine the hypothesis that changes in the cognition (i.e. thinking and memory) after anesthesia and surgery are correlated with changes in markers of Alzheimers Disease in the fluid around the brain and spinal cord (i.e. cerebrospinal fluid, or CSF), and/or changes in brain connectivity. The investigators will also examine whether different types of anesthesia have different effects on these CSF markers of Alzheimers disease, or different effects on thinking and memory after anesthesia and surgery, or differential effects on the correlation between cognitive changes and CSF marker changes.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsAlzheimers Disease, Postoperative Delirium, Post Operative Cognitive Dysfunction
CountriesUnited States
Collaborators--

Timeline

Phase 4CompletedFinished
2014201520162017201820192020202120222023202420252026
First PostedNov 25, 2013
Enrollment StartNov 1, 2013
Primary CompletionJan 10, 2019
TodayJul 2, 2026
Enrollment to primary: 5.2 yearsPosted 12.6 years ago

Interventions

Total intravenous anesthesia with propofoldrug

General anesthesia with isofluranedrug