CI

At a glance

ClinicalIndex Comparison Record
Phase 3Completed· 503 enrolled
Drug / intervention
Lenalidomide +1 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT01996865
NCT01996865Phase 3Completed

A Phase 3B Randomized Study of Lenalidomide (CC-5013) Plus Rituximab Maintenance Therapy Followed by Lenalidomide Single-Agent Maintenance Versus Rituximab Maintenance in Subjects With Relapsed/Refractory Follicular, Marginal Zone, or Mantle Cell Lymphoma

Celgene·interventional·Posted Nov 27, 2013·Updated Jul 10, 2025

In Brief

A Phase 3 clinical trial evaluating Lenalidomide and Rituximab for Lymphoma, Non-Hodgkin. Completed, enrolled 503 participants across 126 sites in 3 countries.

Detailed Summary

Follicular lymphoma (FL), marginal zone lymphoma (MZL), and mantle cell lymphoma (MCL) are distinct histologic types of B-cell NHL. Lenalidomide is an immunomodulatory agent with direct and immune-mediated mechanisms of action, as well as clinical activity in NHL. Recent studies in frontline and relapsed/refractory NHL show high activity for lenalidomide plus rituximab (R2), supporting further study of this combination.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesGermany, Puerto Rico, United States
Collaborators--

Timeline

Phase 3CompletedFinished
2014201520162017201820192020202120222023202420252026
First PostedNov 27, 2013
Enrollment StartApr 1, 2014
Primary CompletionMay 11, 2024
Study CompletionSep 17, 2024
TodayJul 2, 2026
Enrollment to primary: 10.1 yearsPosted 12.6 years ago

Interventions

Lenalidomidedrug

Rituximabdrug