CI

At a glance

ClinicalIndex Comparison Record
Phase 4Completed· 106 enrolled
Drug / intervention
Placebo +1 moredrug
Likely dose
Duloxetine 60mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT02005601
NCT02005601Phase 4Completed
CompareCT.gov

Does Duloxetine Reduce Sub-Acute Pain After Knee Arthroplasty?

Hospital for Special Surgery, New York·interventional·Posted Dec 9, 2013·Updated Aug 29, 2017

In Brief

A Phase 4 clinical trial evaluating Placebo and Duloxetine 60mg for Total Knee Arthroplasty. Completed, enrolled 106 participants across 1 site.

Detailed Summary

We are investigating the impact of duloxetine ("Cymbalta"), a serotonin and norepinephrine reuptake inhibitor, on pain after total knee arthroplasty (TKA). Specifically, the investigators will determine whether duloxetine, 60 mg daily for 2 weeks, reduces pain scores 2 weeks after TKA.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsTotal Knee Arthroplasty
CountriesUnited States
Collaborators--

Timeline

Phase 4CompletedFinished
2014201520162017201820192020202120222023202420252026
First PostedDec 9, 2013
Enrollment StartNov 1, 2013
Primary CompletionMay 1, 2015
Study CompletionAug 1, 2015
TodayJul 2, 2026
Enrollment to primary: 1.5 yearsPosted 12.6 years ago

Interventions

Placebodrug

Patients will receive placebo drug with no active ingredients per dose. 1 capsule will be taken pre-operatively. One capsule once a day until end of POD14.

Duloxetine 60mgdrug

Patients will receive 60mg of duloxetine per dose. 1 capsule will be taken pre-operatively. One capsule once a day until end of POD14.