CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 1,750 enrolled
Drug / intervention
Biomarker blood drawother
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT02014896
NCT02014896N/ACompleted
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Ischemia Care Biomarkers of Acute Stroke Etiology (BASE)

Ischemia Care LLC·observational·Posted Dec 18, 2013·Updated Jul 8, 2020

In Brief

An observational study evaluating Biomarker blood draw for Ischemic Stroke and 6 related conditions. Completed, enrolled 1,750 participants across 22 sites.

Detailed Summary

The proposed study will validate the clinical use of new biomarker blood tests to identify blood components that may differentiate between diverse stroke etiologies and clinical outcomes as listed below: 1. Differentiate between cardioembolic and large artery atherosclerotic ischemic strokes, when hemorrhagic stroke is ruled out. 2. In cases of ischemic strokes of unknown or "cryptogenic" etiology, determine the ability of biomarker blood tests to predict etiology between cardioembolic and large artery atherosclerotic. 3. In cases of cardioembolic ischemic stroke, further differentiation of cardioembolic ischemic strokes into those caused by atrial fibrillation (AF) and those not caused by AF. 4. Differentiate "transient ischemic attacks" (TIAs) from acute ischemic strokes. 5. Differentiate TIAs from non-ischemic "transient neurological events" (TNE) with similar symptoms.

Study Details

Study Typeobservational
Allocation--
Masking--
Primary Purpose--
ConditionsIschemic Stroke, Atrial Fibrillation, Transient Ischemic Attacks, Transient Cerebrovascular Events, Thrombotic Stroke, Stroke of Basilar Artery, Cardioembolic Stroke
CountriesUnited States
Collaborators--

Timeline

N/ACompletedFinished
2014201520162017201820192020202120222023202420252026
First PostedDec 18, 2013
Enrollment StartDec 1, 2013
Primary CompletionNov 1, 2019
Study CompletionJan 1, 2020
TodayJul 2, 2026
Enrollment to primary: 5.9 yearsPosted 12.5 years ago

Interventions

Biomarker blood drawother

Comparison of gene expression profiles using RNA isolated from whole blood.