At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Strengthening the Case for Ongoing Reduction of Exposure to Traffic-Related Air Pollution
In Brief
A clinical study evaluating Allergen, Saline, and 1 other intervention for Allergies. Completed, enrolled 13 participants across 1 site.
Detailed Summary
The study probes the effects of combined exposures to diesel exhaust and allergens on lung function and on the immune system, specifically focusing on the ability of a particle depletion technique to attenuate effects we and others have seen previously. Individuals are exposed to either filtered air (FA), carefully controlled levels of diesel exhaust (DE) or particle-depleted diesel exhaust (PDDE) in our exposure chamber, after which the investigators will administer an inhaled allergen challenge. 48h later, a procedure called bronchoscopy is used to collect samples from the lungs. After 1 month, the entire procedure is to be repeated with one of the alternate exposures. This will be repeated 4 times (4 exposures; 2 filtered air, 1 diesel exhaust, 1 particle-depleted diesel exhaust)
Study Details
Timeline
Interventions
Subject specific allergen is inhaled on day 1 of the triad
Saline is inhaled on day 1 of the triad
High-efficiency particulate filtration of diesel exhaust