CI

At a glance

ClinicalIndex Comparison Record
Early Ph 1Completed· 92 enrolled
Drug / intervention
Rifampin +3 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT02019875
NCT02019875Early Ph 1Completed
CompareCT.gov

Effect of Modulating CYP3A4 Activity on Mineral Homeostasis

University of Washington·interventional·Posted Dec 24, 2013·Updated Apr 19, 2023

In Brief

A Early Phase 1 clinical trial evaluating Rifampin, Clarithromycin, and 2 other interventions for Vitamin D and Calcium Homeostasis. Completed, enrolled 92 participants across 1 site.

Detailed Summary

The purpose of this study is to determine whether changes in the activity of the enzyme CYP3A4 can change the Vitamin D and bone mineral homeostasis.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsVitamin D and Calcium Homeostasis
CountriesUnited States
CollaboratorsNational Institute of General Medical Sciences (NIGMS)

Timeline

Early Ph 1CompletedFinished
2014201520162017201820192020202120222023202420252026
First PostedDec 24, 2013
Enrollment StartJun 1, 2014
Primary CompletionDec 1, 2020
TodayJul 2, 2026
Enrollment to primary: 6.5 yearsPosted 12.5 years ago

Interventions

Rifampindrug

P450 inducer

Clarithromycindrug

CYP3A4 and Pgp inhibitor in both intestine and liiver

Grapefruit Juiceother

CYP3A4 inhibitor in intestine

Placeboother