CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 46 enrolled
Drug / intervention
oxaliplatin +5 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT02047474
NCT02047474Phase 2Completed
CompareCT.gov

Phase II Study of Peri-Operative Modified Folfirinox in Localized Pancreatic Cancer

Yale University·interventional·Posted Jan 28, 2014·Updated Mar 6, 2026

In Brief

A Phase 2 clinical trial evaluating oxaliplatin, leucovorin calcium, and 4 other interventions for Acinar Cell Adenocarcinoma of the Pancreas and 4 related conditions. Completed, enrolled 46 participants across 9 sites.

Detailed Summary

This phase II trial studies how well combination chemotherapy before and after surgery works in treating patients with localized pancreatic cancer. Drugs used in chemotherapy, such as leucovorin calcium, fluorouracil, irinotecan hydrochloride, and oxaliplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving combination chemotherapy before surgery may make the tumor smaller and reduce the amount of normal tissue that needs to be removed. Giving these treatments after surgery may kill any tumor cells that remain after surgery.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsAcinar Cell Adenocarcinoma of the Pancreas, Duct Cell Adenocarcinoma of the Pancreas, Stage I Pancreatic Cancer, Stage IIA Pancreatic Cancer, Stage IIB Pancreatic Cancer
CountriesUnited States
CollaboratorsNational Cancer Institute (NCI)

Timeline

Phase 2CompletedFinished
2014201520162017201820192020202120222023202420252026
First PostedJan 28, 2014
Enrollment StartMar 25, 2014
Primary CompletionAug 16, 2022
Study CompletionJan 14, 2024
TodayJul 2, 2026
Enrollment to primary: 8.4 yearsPosted 12.4 years ago

Interventions

oxaliplatindrug

Given IV

leucovorin calciumdrug

Given IV

irinotecan hydrochloridedrug

Given IV

fluorouracildrug

Given IV

therapeutic conventional surgeryprocedure

Undergo surgical resection

laboratory biomarker analysisother

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