CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 160 enrolled
Drug / intervention
Indoximod +3 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT02052648
NCT02052648Phase 2Completed

A Phase I/II Study of the Combination of Indoximod and Temozolomide for Adult Patients With Temozolomide-Refractory Primary Malignant Brain Tumors

NewLink Genetics Corporation·interventional·Posted Feb 3, 2014·Updated Mar 27, 2024

In Brief

A Phase 2 clinical trial evaluating Indoximod, Temozolomide, and 2 other interventions for Glioblastoma Multiforme and 3 related conditions. Completed, enrolled 160 participants across 17 sites.

Detailed Summary

In this study, investigators will conduct a phase I/II trial in recurrent (temozolomide resistant) glioma patients. The overall goal of this study is to provide a foundation for future studies with indoximod tested in newly diagnosed glioblastoma patients with radiation and temozolomide, or in combination with vaccine therapies.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesUnited States
Collaborators--

Timeline

Phase 2CompletedFinished
2014201520162017201820192020202120222023202420252026
First PostedFeb 3, 2014
Enrollment StartMar 1, 2014
Primary CompletionApr 18, 2018
Study CompletionJun 20, 2019
TodayJul 2, 2026
Enrollment to primary: 4.1 yearsPosted 12.4 years ago

Interventions

Indoximoddrug

Temozolomidedrug

Bevacizumabdrug

Stereotactic Radiationradiation