CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 35 enrolled
Drug / intervention
Carboplatin +5 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT02073968
NCT02073968Phase 2Completed
CompareCT.gov

PET-Adjusted IMRT for NSCLC Trial (PAINT)

Albert Einstein College of Medicine·interventional·Posted Feb 28, 2014·Updated Jan 25, 2024

In Brief

A Phase 2 clinical trial evaluating Carboplatin, Computed Tomography, and 4 other interventions for Metastatic Malignant Neoplasm in the Brain and 6 related conditions. Completed, enrolled 35 participants across 2 sites.

Detailed Summary

This phase II trial studies how well intensity modulated radiation therapy adjusted by positron emission tomography (PET) scanning together with combination chemotherapy works in treating patients with stage II-IV non-small cell lung cancer (NSCLC). Radiation therapy uses high energy x rays to kill tumor cells. In intensity-modulated radiotherapy, multiple beam angles and dozens of beam segments are used to deliver highly conformal radiation therapy. Drugs used in chemotherapy, such as carboplatin and paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving PET-adjusted IMRT together with combination chemotherapy may kill more tumor cells.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsMetastatic Malignant Neoplasm in the Brain, Recurrent Non-Small Cell Lung Carcinoma, Stage IIA Non-Small Cell Lung Carcinoma, Stage IIB Non-Small Cell Lung Carcinoma, Stage IIIA Non-Small Cell Lung Cancer, Stage IIIB Non-Small Cell Lung Cancer, Stage IV Non-Small Cell Lung Cancer
CountriesUnited States
CollaboratorsNational Cancer Institute (NCI)

Timeline

Phase 2CompletedFinished
2014201520162017201820192020202120222023202420252026
First PostedFeb 28, 2014
Enrollment StartJul 1, 2013
Primary CompletionDec 1, 2017
Study CompletionNov 1, 2020
TodayJul 2, 2026
Enrollment to primary: 4.4 yearsPosted 12.3 years ago

Interventions

Carboplatindrug

Given IV

Computed Tomographyprocedure

Undergo PET-adjusted IMRT

Intensity-Modulated Radiation Therapyradiation

Undergo PET-adjusted IMRT

Paclitaxeldrug

Given IV

Positron Emission Tomographyprocedure

Undergo PET-adjusted IMRT

Proton Beam Radiation Therapyradiation

Undergo proton beam radiation therapy