CI

At a glance

ClinicalIndex Comparison Record
Phase 3Completed· 676 enrolled
Drug / intervention
AIN457 300 mg +2 moredrug
Likely dose
AIN457 300 mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT02074982
NCT02074982Phase 3Completed

A 52-week, Multicenter, Randomized, Double-blind Study of Subcutaneous Secukinumab to Demonstrate Efficacy as Assessed by Psoriasis Area and Severity Index at 16 Weeks of Treatment Compared to Ustekinumab and to Assess Long-term Safety, Tolerability and Efficacy in Subjects With Moderate to Severe Plaque Psoriasis (CLEAR)

Novartis Pharmaceuticals·interventional·Posted Mar 3, 2014·Updated Jul 21, 2017

In Brief

A Phase 3 clinical trial evaluating AIN457 300 mg, ustekinumab 45/90 mg, and 1 other intervention for Chronic Plaque Type Psoriasis. Completed, enrolled 676 participants across 137 sites in 24 countries.

Detailed Summary

This study assessed efficacy of secukinumab, compared to ustekinumab, in patients that have plaque-type psoriasis

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesAustralia, Austria, Belgium, Bulgaria, Canada, Denmark, Estonia, France, Germany, Greece, Hungary, Israel, Italy, Netherlands, Norway, Portugal, Slovakia, South Korea, Spain, Switzerland, Taiwan, Turkey (Türkiye), United Kingdom, United States
Collaborators--

Timeline

Phase 3CompletedFinished
2014201520162017201820192020202120222023202420252026
First PostedMar 3, 2014
Enrollment StartFeb 26, 2014
Primary CompletionJun 29, 2016
TodayJul 2, 2026
Enrollment to primary: 2.3 yearsPosted 12.3 years ago

Interventions

AIN457 300 mgdrug

ustekinumab 45/90 mgdrug

placebo secukinumabdrug

Placebo