At a glance
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Effect of Amygdala Neurofeedback on Depressive Symptoms and Processing Biases
In Brief
A clinical study evaluating real-time fMRI neurofeedback: Amygdala and real-time fMRI neurofeedback: HIPS for Major Depressive Disorder. Completed, enrolled 36 participants across 1 site.
Detailed Summary
The purpose of this study is to determine whether upregulating the left amygdala during positive autobiographical memory recall via real time functional magnetic resonance imaging neurofeedback will lead to an improvement in clinician administered ratings of depressive symptoms. The investigators predict that patients with major depressive disorder receiving left amygdala neurofeedback will increase their amygdala response during positive autobiographical memory recall compared to those receiving control feedback from a region not involved in emotional processing and that this ability will be associated with clinically significant improvement.
Study Details
Timeline
Interventions
Participants are shown activity from their left amygdala in real time and are instructed to increase the level of activity in that region by thinking of positive autobiographical memories.
Participants are shown activity from their left horizontal segment of the intraparietal sulcus in real time and are instructed to increase the level of activity in that region by thinking of positive autobiographical memories.