CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 131 enrolled
Drug / intervention
levodopa/carbidopa 400/100 BIDdrug
Likely dose
levodopa/carbidopa 400/100 BID 12.5 mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT02080819
NCT02080819Phase 2Completed
CompareCT.gov

Striatal Effective Connectivity to Predict Treatment Response in Cocaine Misuse

Virginia Commonwealth University·interventional·Posted Mar 6, 2014·Updated Apr 12, 2018

In Brief

A Phase 2 clinical trial evaluating levodopa/carbidopa 400/100 BID for Cocaine Dependence. Completed, enrolled 131 participants across 1 site.

Detailed Summary

This project proposes to investigate the role of brain connectivity in the mechanism of treatment response to dopaminergic medications in cocaine dependence.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsCocaine Dependence
CountriesUnited States
CollaboratorsNational Institute on Drug Abuse (NIDA)

Timeline

Phase 2CompletedFinished
2014201520162017201820192020202120222023202420252026
First PostedMar 6, 2014
Enrollment StartFeb 1, 2014
Primary CompletionJan 21, 2017
TodayJul 2, 2026
Enrollment to primary: 3.0 yearsPosted 12.3 years ago

Interventions

levodopa/carbidopa 400/100 BIDdrug

Levodopa dose escalation (1 week): Days 1-2, one 50/12.5 mg tablet BID; Days 3-4, one 100/25 mg tablet BID; Days 5-6, one 200/50 mg tablet BID; Day 7, one 400/100 mg tablet BID. Maintenance phase (7 weeks): One 400/100 mg Levodopa/Carbidopa tablet BID or placebo in conjunction with once weekly individual cognitive behavioral therapy plus contingency management for attendance.