At a glance
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Duration of Red Blood Cell Storage Prior to Transfusion and Non-Transferrin-Bound Iron
In Brief
A clinical study evaluating Blood Transfusion and Packed red blood cells for Iron, Blood Level Abnormal. Completed, enrolled 60 participants across 1 site.
Detailed Summary
This study will determine the minimal duration of red blood cell (RBC) storage that leads to increases in circulating non-transferrin-bound iron in healthy human volunteers post-transfusion. The results from this study will help guide national guidelines for appropriate duration of RBC storage prior to transfusion, which is currently 6 weeks by Food and Drug Administration (FDA) criteria. The overall objective of this research is to improve the safety of refrigerated storage of red blood cells before transfusion.
Study Details
Timeline
Interventions
A routine medical procedure in which blood is given through an intravenous (IV) line a blood vessel.
Red blood cells that have been collected, processed, and stored in bags as blood product units available for blood transfusion. A standard autologous leukoreduced packed red blood cell unit will be collected and stored in AS-3 solution in the Columbia University Medical Center blood bank. The number of weeks in storage are as follows: * 1 week * 2 weeks * 3 weeks * 4 weeks * 5 weeks * 6 weeks