At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Small Intestinal Adaptation to Isocaloric Diets Dominated Either by Fats or Carbohydrates
In Brief
A clinical study evaluating high fat diet (hfd), then high carbohydrate diet and high carbohydrate diet, then high fat diet for Healthy Conditions. Completed, enrolled 17 participants across 1 site.
Detailed Summary
Human beings are 'omnivores' meaning that all principal components of food (i.e. the macronutrients: carbohydrates, fat, proteins) can be assimilated by the gastrointestinal tract. When the gut mucosa is exposed to dietary changes it adjusts its functional behaviour. For example, a fatty diet demands certain digestive mechanisms, whereas others are needed to take care of a carbohydrate rich diet. Such dietary induced changes in appearance and functionality of the small intestinal mucosa have been described in animals but only little is known about it in man. The present project aims at elucidating in man if a 2 weeks diet dominated by either fat or carbohydrates, but with similar energy content, is associated with changes in the small intestinal mucosal appearance and metabolic signalling capacity.
Study Details
Timeline
Interventions
Sixty % of the energy content is based on fat, then sixty % of the energy content is based on carbohydrates
Sixty % of the energy content is based on carbohydrates, then sixty % of the energy content is based on fat