CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 2,486 enrolled
Drug / intervention
Carotid endarterectomy (CEA) +3 moreprocedure
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT02089217
NCT02089217N/ACompleted
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Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial

Mayo Clinic·interventional·Posted Mar 17, 2014·Updated Oct 1, 2025

In Brief

A clinical study evaluating Carotid endarterectomy (CEA), Carotid Stenting (CAS), and 2 other interventions for Carotid Stenosis. Completed, enrolled 2,486 participants across 167 sites in 5 countries.

Detailed Summary

Carotid revascularization for primary prevention of stroke (CREST-2) is two independent multicenter, randomized controlled trials of carotid revascularization and intensive medical management versus medical management alone in patients with asymptomatic high-grade carotid stenosis. One trial will randomize patients in a 1:1 ratio to endarterectomy versus no endarterectomy and another will randomize patients in a 1:1 ratio to carotid stenting with embolic protection versus no stenting. Medical management will be uniform for all randomized treatment groups and will be centrally directed.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsCarotid Stenosis
CountriesAustralia, Canada, Israel, Spain, United States
CollaboratorsNational Institute of Neurological Disorders and Stroke (NINDS)

Timeline

N/ACompletedFinished
2014201520162017201820192020202120222023202420252026
First PostedMar 17, 2014
Enrollment StartDec 9, 2014
Primary CompletionSep 12, 2025
TodayJul 2, 2026
Enrollment to primary: 10.8 yearsPosted 12.3 years ago

Interventions

Carotid endarterectomy (CEA)procedure

Carotid endarterectomy

Carotid Stenting (CAS)device

Carotid stenting

Intensive Medical Management - no CEAother

Intensive Medical Management alone - no CEA

Intensive Medical Management - no CASother

Intensive Medical Management alone - no CAS