CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 33 enrolled
Drug / intervention
transcranial Direct Current Stimulationdevice
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT02091167
NCT02091167Phase 2Completed
CompareCT.gov

Prefrontal Modulation by Repetitive Bilateral Transcranial Direct Current Stimulation (tDCS) in Crack-cocaine Addicted Inpatients.

Federal University of Espirito Santo·interventional·Posted Mar 19, 2014·Updated Jun 24, 2019

In Brief

A Phase 2 clinical trial evaluating transcranial Direct Current Stimulation for Drug Addiction and Executive Dysfunction. Completed, enrolled 33 participants across 1 site.

Detailed Summary

In this study, eligible crack-cocaine addicted inpatients recruited from specialized clinics for substance abuse disorder treatment, filling inclusion criteria and not showing any exclusion criteria, were randomized to receive the repetitive (10 sessions, every other day) bilateral dorsolateral Prefrontal Cortex (dlPFC: cathodal left / anodal right) tDCS (2 milliamperes, 3x7 cm2, for 20 min) or placebo (sham-tDCS). Craving to the use of crack-cocaine was examined before (baseline), during and after the end of the tDCS treatment. Based in our previous data, our hypothesis was that repetitive bilateral tDCS over dlPFC would favorably change clinical, cognitive and brain function in crack-cocaine addiction and these would be long-lasting effects.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsDrug Addiction, Executive Dysfunction
CountriesBrazil
CollaboratorsConselho Nacional de Desenvolvimento Científico e Tecnológico, Harvard Medical School (HMS and HSDM), University of Göttingen

Timeline

Phase 2CompletedFinished
2014201520162017201820192020202120222023202420252026
First PostedMar 19, 2014
Enrollment StartNov 1, 2013
Primary CompletionJul 1, 2018
TodayJul 2, 2026
Enrollment to primary: 4.7 yearsPosted 12.3 years ago

Interventions

transcranial Direct Current Stimulationdevice

Direct currents are transferred via a pair of carbonated-silicone electrodes (35 cm2) with a thick layer of high conductive gel for EEG underneath them. The electric current is delivered by an electric stimulator. To stimulate the left DLPFC, the cathode electrode is placed over F3 according to the 10-20 international system while the anode is placed over the contralateral F4 region. The currents flows continuously for 20 minutes with an intensity of 2 milliamperes.