CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 1,500 enrolled
Drug / intervention
FFR guided PCI +3 moreprocedure
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT02100722
NCT02100722N/ACompleted
CompareCT.gov

Fractional Flow Reserve Versus Angiography for Multivessel Evaluation (FAME) 3 Trial A Comparison of Fractional Flow Reserve-Guided Percutaneous Coronary Intervention and Coronary Artery Bypass Graft Surgery in Patients With Multivessel Coronary Artery Disease

Stanford University·interventional·Posted Apr 1, 2014·Updated Apr 7, 2026

In Brief

A clinical study evaluating FFR guided PCI, CABG, and 2 other interventions for Coronary Disease and Coronary Stenosis. Completed, enrolled 1,500 participants across 46 sites in 16 countries.

Detailed Summary

The purpose of this study is to determine whether Fractional flow reserve (FFR, (coronary pressure wire-based index for assessing the ischemic potential of a coronary lesion)-guided percutaneous coronary intervention (PCI) in patients with multivessel coronary artery disease (CAD) will result in similar outcomes to coronary artery bypass graft surgery (CABG).

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsCoronary Disease, Coronary Stenosis
CountriesAustralia, Belgium, Canada, Czechia, Denmark, France, Hungary, Lithuania, Netherlands, New Zealand, Norway, Serbia, South Korea, Sweden, United Kingdom, United States
CollaboratorsVZW Cardiovascular Research Center Aalst, Catharina Ziekenhuis Eindhoven, Golden Jubilee National Hospital, University of California, Irvine, Medtronic, Abbott Medical Devices, Genae, King's College Hospital NHS Trust, Houston Methodist DeBakey Heart & Vascular Center

Timeline

N/ACompletedFinished
2014201520162017201820192020202120222023202420252026
First PostedApr 1, 2014
Enrollment StartAug 25, 2014
Primary CompletionDec 1, 2020
Study CompletionDec 1, 2024
TodayJul 2, 2026
Enrollment to primary: 6.3 yearsPosted 12.3 years ago

Interventions

FFR guided PCIprocedure

CABGprocedure

Coronary Artery Bypass Graft Surgery (CABG)

Resolute Integrity Stentdevice

Durable polymer zotarolimus-eluting stent

Resolute Onyx Stentdevice

Durable polymer zotarolimus-eluting stent