At a glance
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Vitamin C Infusion for Treatment in Sepsis Induced Acute Lung Injury
In Brief
A Phase 2 clinical trial evaluating Ascorbic Acid and Placebo: 5% Dextrose in water for Acute Lung Injury and Sepsis. Completed, enrolled 170 participants across 5 sites.
Detailed Summary
Hypothesis 1A: Vitamin C infusion will significantly attenuate sepsis-induced systemic organ failure as measured by Sequential Organ Failure Assessment (SOFA) score, Hypothesis 1B: Vitamin C infusion will attenuate sepsis-induced lung injury as assessed by the oxygenation index and the VE40 Hypothesis 1C: Vitamin C infusion will attenuate biomarkers of inflammation (C-Reactive Protein, Procalcitonin), vascular injury (Thrombomodulin, Angiopoietin-2), alveolar epithelial injury (Receptor for Advanced Glycation Products), while inducing the onset of a fibrinolytic state (Tissue Factor Pathway Inhibitor).
Study Details
Timeline
Interventions
Intervention
Placebo