At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Breathlessness Perception in COPD: Relationship With Exacerbation Frequency
In Brief
A clinical study evaluating Spirometry, CO Exhaled breath, and 2 other interventions for Dyspnea. Completed, enrolled 34 participants across 1 site.
Detailed Summary
The perception of breathlessness varies significantly among COPD patients with similar severity of airflow limitation; those with poorer perception report less exacerbations as compared to those with frequent exacerbations. Cross-sectional comparison of breathlessness perception in COPD patients with frequent exacerbations or without frequent exacerbations. To assess "Breathlessness Perception" the investigators will increase the ventilatory demand of the patients by CO2-rebreathing method.
Study Details
Timeline
Interventions
Before re-breathing (if the patient not performed one 6 months in advance).
In current smokers of both arms to confirm that the patient has not smoked in the past three hours and to asses the smoking status (heavy, moderate, light).
P01 is the negative airway pressure generated during the first 100 ms of an occluded inspiration. It's an estimation of the neuromuscular drive to breathe.
The measurement of fraction of exhaled nitric oxide during exacerbations of COPD is higher than normal.