CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 204 enrolled
Drug / intervention
Identification of biological markersbiological
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT02113917
NCT02113917N/ACompleted
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The Formation of a Cohort of HLHa Patients in Order to Study Their Physiopathological Characteristics

Assistance Publique - Hôpitaux de Paris·observational·Posted Apr 15, 2014·Updated Nov 20, 2025

In Brief

An observational study evaluating Identification of biological markers for Hemophagocytic Syndrome. Completed, enrolled 204 participants across 1 site.

Detailed Summary

Different study of HLHa patients : * Diagnosis criteria, because criteria are based on pediatric genetic studies. * Physiopathological studies: genetic studies have demonstrated the role of CD8+ cells, in particular because they have a genetic defect affecting their cytotoxic functions in HLH pediatric. the aim is to establish if the same defect is found in both some or in all of HLHa patients. If this is the case, to then establish whether hypomorphic genetic mutations are responsible.

Study Details

Study Typeobservational
Allocation--
Masking--
Primary Purpose--
ConditionsHemophagocytic Syndrome
CountriesFrance
CollaboratorsLaboratory of normal and pathological development Immune System - IFR 94 U768, Reference Centre for Hereditary Immunodeficiency: CEREDIH, URC-CIC Paris Descartes Necker Cochin

Timeline

N/ACompletedFinished
20102011201220132014201520162017201820192020202120222023202420252026
First PostedApr 15, 2014
Enrollment StartJan 1, 2010
Primary CompletionJan 1, 2016
Study CompletionJan 12, 2017
TodayJul 2, 2026
Enrollment to primary: 6 yearsPosted 12.2 years ago

Interventions

Identification of biological markersbiological