CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 327 enrolled
Drug / intervention
Dose Level A / Brinzolamide 1% ophthalmic suspension +6 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT02140060
NCT02140060Phase 2Completed
CompareCT.gov

A 6-Week Proof-of-Concept Study Evaluating the Safety and IOP-Lowering Efficacy of Travoprost/Brinzolamide Fixed Combination Ophthalmic Suspension in Subjects With Open-Angle Glaucoma or Ocular Hypertension

Alcon Research·interventional·Posted May 16, 2014·Updated Dec 29, 2015

In Brief

A Phase 2 clinical trial evaluating Dose Level A / Brinzolamide 1% ophthalmic suspension, Dose Level B / Brinzolamide 1% ophthalmic suspension, and 5 other interventions for Glaucoma and Ocular Hypertension. Completed, enrolled 327 participants.

Detailed Summary

The purpose of this study is to evaluate Travoprost/Brinzolamide fixed combination (Trav/Brinz) administered twice daily as compared to each of its marketed components (TRAVATAN Z® solution and AZOPT® suspension) and to the unfixed combination of TRAVATAN Z® plus AZOPT® in lowering intraocular pressure (IOP).

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsGlaucoma, Ocular Hypertension
Countries--
Collaborators--

Timeline

Phase 2CompletedFinished
201520162017201820192020202120222023202420252026
First PostedMay 16, 2014
Enrollment StartJun 1, 2014
Primary CompletionNov 1, 2014
TodayJul 2, 2026
Enrollment to primary: 5 monthsPosted 12.1 years ago

Interventions

Dose Level A / Brinzolamide 1% ophthalmic suspensiondrug

Fixed combination

Dose Level B / Brinzolamide 1% ophthalmic suspensiondrug

Fixed combination

Dose Level C / Brinzolamide 1% ophthalmic suspensiondrug

Fixed combination

Brinzolamide 1% ophthalmic suspension AZOPT®drug

Travoprost 0.004% ophthalmic solution TRAVATAN Z®drug

Travoprost solution vehicledrug

Inactive ingredients used for masking purposes

Brinzolamide suspension vehicledrug

Inactive ingredients used for masking purposes