At a glance
ClinicalIndex Comparison RecordEarly Ph 1Completed· 15 enrolled
Drug / intervention
Cocaine +2 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Motivation for Cocaine and Non-Drug Reinforcers: Targeting Glutamate Homeostasis
In Brief
A Early Phase 1 clinical trial evaluating Cocaine, n-Acetylcysteine, and 1 other intervention for Cocaine Abuse and Cocaine Dependence. Completed, enrolled 15 participants across 1 site.
Detailed Summary
This study will determine the initial efficacy, safety and tolerability of n-acetylcysteine as a pharmacotherapy for cocaine dependence. A rigorous, inpatient human laboratory study will be conducted in which the subjective, physiological and reinforcing effects of cocaine are evaluated during maintenance on placebo and n-acetylcysteine.
Study Details
Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsCocaine Abuse, Cocaine Dependence
CountriesUnited States
CollaboratorsNational Institute on Drug Abuse (NIDA)
Timeline
Early Ph 1CompletedFinished
2014201520162017201820192020202120222023202420252026
Enrollment StartMay 2014
First PostedMay 2014
Primary CompletionApr 2016
TodayJul 2026
First PostedMay 19, 2014
Enrollment StartMay 1, 2014
Primary CompletionApr 1, 2016
TodayJul 2, 2026
Enrollment to primary: 1.9 yearsPosted 12.1 years ago
Interventions
Cocainedrug
The pharmacodynamic effects of cocaine will be determined during maintenance on placebo and n-acetylcysteine.
n-Acetylcysteinedrug
Placebodrug