CI

At a glance

ClinicalIndex Comparison Record
Phase 1Completed· 21 enrolled
Drug / intervention
750 milligram Xentuzumab +2 moredrug
Likely dose
750 milligram Xentuzumabfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT02145741
NCT02145741Phase 1Completed

An Open-label Phase I Dose Escalation Trial of Weekly Intravenous Administrations of BI 836845 in Japanese Patients With Advanced Solid Tumours

Boehringer Ingelheim·interventional·Posted May 23, 2014·Updated Jun 19, 2025

In Brief

A Phase 1 clinical trial evaluating 750 milligram Xentuzumab, 1000 milligram Xentuzumab, and 1 other intervention for Neoplasms. Completed, enrolled 21 participants across 1 site.

Detailed Summary

This open-label dose escalation phase I trial, 1280.15, is with the first administration of BI 836845 in Japanese patients with various types of advanced solid tumours. The rationale behind this study is to identify the maximum tolerated dose (MTD) of BI 836845 in Japanese patients with advanced solid tumours as weekly intravenous administration.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsNeoplasms
CountriesJapan
Collaborators--

Timeline

Phase 1CompletedFinished
201520162017201820192020202120222023202420252026
First PostedMay 23, 2014
Enrollment StartJun 11, 2014
Primary CompletionJul 1, 2015
Study CompletionJul 14, 2023
TodayJul 2, 2026
Enrollment to primary: 1.1 yearsPosted 12.1 years ago

Interventions

750 milligram Xentuzumabdrug

750 milligram Xentuzumab given weekly (days 1, 8, and 15) as an intravenous infusion over 1 hour. Patients stayed on treatment in 21-day cycles until disease progression or undue toxicities.

1000 milligram Xentuzumabdrug

1000 milligram Xentuzumab given weekly (days 1, 8, and 15) as an intravenous infusion over 1 hour. Patients stayed on treatment in 21-day cycles until disease progression or undue toxicities.

1400 milligram Xentuzumabdrug

1400 milligram Xentuzumab given weekly (days 1, 8, and 15) as an intravenous infusion over 1 hour. Patients stayed on treatment in 21-day cycles until disease progression or undue toxicities.