At a glance
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A Biomarker-Driven Master Protocol for Previously Treated Squamous Cell Lung Cancer (Lung-Map)
In Brief
An observational study evaluating Docetaxel, Durvalumab, and 11 other interventions for Recurrent Squamous Cell Lung Carcinoma and Stage IV Squamous Cell Lung Carcinoma AJCC v7. Completed, enrolled 1,864 participants across 1,004 sites in 2 countries.
Detailed Summary
This screening and multi-sub-study randomized phase II/III trial will establish a method for genomic screening of similar large cancer populations followed by assigning and accruing simultaneously to a multi-sub-study hybrid ?Master Protocol? (S1400). The type of cancer trait (biomarker) will determine to which sub-study, within this protocol, a participant will be assigned to compare new targeted cancer therapy, designed to block the growth and spread of cancer, or combinations to standard of care therapy with the ultimate goal of being able to approve new targeted therapies in this setting. In addition, the protocol includes a ?non-match? sub-study which will include all screened patients not eligible for any of the biomarker-driven sub-studies. This sub-study will compare a non-match therapy to standard of care also with the goal of approval.
Study Details
Timeline
Interventions
Given IV
Given IV
Given PO
Given PO
Given IV
Correlative studies
Given IV
Given PO
Correlative studies
Given IV
Given PO
Given PO
Given IV