At a glance
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Endoscopic Ultrasound-guided Ethanol Injection of Pancreatic Cystic Neoplasms
In Brief
A Phase 1 clinical trial evaluating Ethanol and Lidocaine for Neoplasms, Cystic, Mucinous, and Serous. Completed, enrolled 33 participants across 1 site.
Detailed Summary
Cystic tumors of the pancreas are fluid-filled growths. They are often treated by surgical removal. A safe and effective non-surgical treatment is desirable. Ethanol (alcohol) injection may treat cysts by killing the lining cells of the cyst, and is an accepted treatment for cysts of other organs. In this study, participants with pancreatic cysts underwent endoscopic ultrasound (EUS) guided ethanol injection of pancreatic cysts. This was a pilot study to assess safety and efficacy. The hypotheses of this study were 1) complications of EUS guided ethanol injection requiring hospitalization will occur in \<10% of subjects, and 2) EUS guided ethanol injection, with retreatment as necessary, will ablate at least 50% of pancreatic cysts.
Study Details
Timeline
Interventions
EUS-guided lavage of a pancreatic cystic neoplasm with ethanol solution. Ethanol was diluted to 80% using normal saline.
The final solution contained 1% lidocaine except in subjects allergic to local anesthetics.