CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 103 enrolled
Drug / intervention
Mifepristone 1200 mg daily +2 moredrug
Likely dose
Mifepristone 1200 mg dailyfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT02179749
NCT02179749Phase 2Completed
CompareCT.gov

Glucocorticoid Antagonist Treatment of Alcohol Use Disorder

The Scripps Research Institute·interventional·Posted Jul 2, 2014·Updated Oct 6, 2022

In Brief

A Phase 2 clinical trial evaluating Mifepristone 1200 mg daily, Standardized behavioral therapy, and 1 other intervention for Alcohol Dependence and 3 related conditions. Completed, enrolled 103 participants across 1 site.

Detailed Summary

This is an 8-week, randomized, double-blind, placebo-controlled, 2 arm, parallel groups, study of 1-week of treatment with mifepristone (0, 1200 mg/d) given in conjunction with 8 weeks of manual-guided counseling, and a follow-up visit at Week 12.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsAlcohol Dependence, Alcohol Use Disorders, Alcohol Abuse, Alcoholism
CountriesUnited States
CollaboratorsNational Institute on Alcohol Abuse and Alcoholism (NIAAA)

Timeline

Phase 2CompletedFinished
201520162017201820192020202120222023202420252026
First PostedJul 2, 2014
Enrollment StartSep 1, 2014
Primary CompletionNov 1, 2019
Study CompletionNov 6, 2019
TodayJul 2, 2026
Enrollment to primary: 5.2 yearsPosted 12 years ago

Interventions

Mifepristone 1200 mg dailydrug

Mifepristone, 300 mg tablets, Four tablets daily/am for 1-week duration.

Standardized behavioral therapybehavioral

Standardized behavioral therapy 1 time per week for 8 week duration.

Placebodrug

Placebo tablets, Four tablets daily/am for 1-week duration.