At a glance
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Comparison of Different Efficacy of Macrolide and Glucocorticoid in the Treatment of Chronic Rhinosinusitis Patients After Endoscopic Sinus Surgery
In Brief
A clinical study evaluating Clarithromycin and Glucocorticoid for Chronic Rhinosinusitis and Endoscopic Sinus Surgery. Completed, enrolled 187 participants across 1 site.
Detailed Summary
Endoscopic sinus surgery (ESS) is widely considered to be the gold standard in the surgical management of chronic rhinosinusitis (CRS) that has failed maximal medical therapy. Nevertheless, the postoperation medical therapy was considered as a crucial procedure for the success of ESS. Both glucocorticoids and macrolide antibiotics have been recommended for the treatment of CRS, but their effect as postoperation medical therapies of ESS need more clinical data to clarify. The purpose of this prospective, randomized,study is to determine the effect of glucocorticoids and macrolide antibiotics for the postoperation medical therapy of ESS in different subtypes of CRS.
Study Details
Timeline
Interventions
Clarithromycin 250 mg tablet once daily for 3 months
Fluticasone propionate nasal spray 200 μg/d for 3 months