CI

At a glance

ClinicalIndex Comparison Record
Phase 4Completed· 20 enrolled
Drug / intervention
Ticagrelor loading dose +3 moredrug
Likely dose
Ticagrelor loading dose 180 mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT02201394
NCT02201394Phase 4Completed
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Normalizing Platelet Reactivity After Treatment With Ticagrelor

Icahn School of Medicine at Mount Sinai·interventional·Posted Jul 28, 2014·Updated Dec 5, 2017

In Brief

A Phase 4 clinical trial evaluating Ticagrelor loading dose, Aspirin loading dose, and 2 other interventions for Coronary Artery Disease. Completed, enrolled 20 participants across 1 site.

Detailed Summary

Acute coronary syndrome (ACS) patients treated with antiplatelet drugs who require coronary artery bypass grafting (CABG) surgery have to wait 5-7 days for the effects of the drugs to wean off. This treatment-devoid period leaves the patient vulnerable, therefore any means to shorten this period could be useful. The present study aims to investigate the possibility of reversing the antiplatelet effects of ticagrelor with the help of fresh donor platelets. Fresh platelets will be added to blood samples of treated patients in varying concentrations at specific timepoints to determine the time and amount of fresh platelets needed to normalize platelet reactivity in the treated samples.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsCoronary Artery Disease
CountriesUnited States
CollaboratorsAstraZeneca

Timeline

Phase 4CompletedFinished
201520162017201820192020202120222023202420252026
First PostedJul 28, 2014
Enrollment StartJul 1, 2014
Primary CompletionJun 1, 2016
TodayJul 2, 2026
Enrollment to primary: 1.9 yearsPosted 11.9 years ago

Interventions

Ticagrelor loading dosedrug

Single loading dose of Ticagrelor 180 mg

Aspirin loading dosedrug

Single loading dose of Aspirin 325 mg

Ticagrelor maintenance dosedrug

Ticagrelor 90 mg twice daily x 7 days

Aspirin maintenance dosedrug

Aspirin 81 mg once daily x 7 days