At a glance
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The Effects of Hydromorphone on Responses to Verbal Tasks
In Brief
A clinical study evaluating 2 mg hydromorphone, 1000 mg Acetaminophen, and 2 other interventions for Healthy. Completed, enrolled 50 participants across 1 site.
Detailed Summary
In this study, the investigators will examine the effects of hydromorphone, as compared to placebo, upon physiological, subjective, and hormonal responses to a stressful speech task and a non-stressful control task in healthy adults. There is strong evidence in support of the role of endogenous opioids and opiates in mediating social behavior in humans and other animals, and particularly, in social distress. The investigators have recently shown that buprenorphine, a partial mu-opioid agonist, reduces cortisol responses to stress. Here, the investigators propose to further explore the role of the opioid system in mediating stress responses in humans through the use of hydromorphone, a full mu opioid agonist, in addition to acetaminophen. The investigators hypothesize that like acetaminophen, hydromorphone will reduce both physiological and subjective measures of stress.
Study Details
Timeline
Interventions
We are administering oral hydromorphone to healthy volunteers to measure its effects on the performance of a verbal task.
We are administering sublingual buprenorphine to healthy volunteers to measure its effects on the performance of a verbal task.
We are administering oral hydromorphone to healthy volunteers to measure its effects on the performance of a verbal task.
We are administering dextrose to healthy volunteers for our placebo group.