CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 65 enrolled
Drug / intervention
Roux-en-Y gastric bypass surgery +1 moreprocedure
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT02207777
NCT02207777N/ACompleted
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Weight Loss-Independent Metabolic Effects of Roux-En-Y Gastric Bypass in Diabetes

Washington University School of Medicine·interventional·Posted Aug 4, 2014·Updated Jul 20, 2025

In Brief

A clinical study evaluating Roux-en-Y gastric bypass surgery and Low-calorie diet for Obesity and Type 2 Diabetes. Completed, enrolled 65 participants across 1 site.

Detailed Summary

For this purpose, we will compare the effects of targeted 16-18% (with a range of 16-25%) weight loss induced by Roux-en-Y Gastric bypass (RYGB) surgery with the same weight loss induced by a low-calorie diet (LCD) on liver and skeletal muscle insulin sensitivity, beta-cell function, and 24-hour metabolic homeostasis in obese subjects with or without T2D.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsObesity, Type 2 Diabetes
CountriesUnited States
CollaboratorsNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Timeline

N/ACompletedFinished
201520162017201820192020202120222023202420252026
First PostedAug 4, 2014
Enrollment StartAug 1, 2014
Primary CompletionMar 1, 2019
TodayJul 2, 2026
Enrollment to primary: 4.6 yearsPosted 11.9 years ago

Interventions

Roux-en-Y gastric bypass surgeryprocedure

A surgical procedure to help subjects lose approximately 16-18% (with a range of 16-25%) of their body weight.

Low-calorie dietbehavioral

Subjects will meet with a dietitian and/or behaviorist over approximately 6 months to lose approximately 16-18% (with a range of 16-25%) of their body weight.