CI

At a glance

ClinicalIndex Comparison Record
Phase 1Completed· 84 enrolled
Drug / intervention
PF-06293620 +17 morebiological
Likely dose
PF-06293620 0.3 mg/kgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT02211261
NCT02211261Phase 1Completed

A Phase 1 Double-blind, Placebo-controlled, Randomized, Single- And Multiple-ascending Dose Study To Assess The Safety, Tolerability, And Pharmacokinetics Of Pf-06293620 In Subjects With Type 2 Diabetes Mellitus

Pfizer·interventional·Posted Aug 7, 2014·Updated Oct 16, 2018

In Brief

A Phase 1 clinical trial evaluating PF-06293620 and Placebo for Type 2 Diabetes Mellitus. Completed, enrolled 84 participants across 7 sites.

Detailed Summary

A first in human study to determine the safety, tolerability and pharmacokinetics of single and multiple ascending doses of PF-06293620 in subjects with Type 2 Diabetes Mellitus

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesUnited States
Collaborators--

Timeline

Phase 1CompletedFinished
201520162017201820192020202120222023202420252026
First PostedAug 7, 2014
Enrollment StartSep 15, 2014
Primary CompletionJan 27, 2017
TodayJul 2, 2026
Enrollment to primary: 2.4 yearsPosted 11.9 years ago

Interventions

PF-06293620biological

subcutaneous, single dose 0.3 mg/kg

Placebobiological

Subcutaneous normal saline single dose

PF-06293620biological

Subcutaneous, single dose 1.0 mg/kg

Placebobiological

Subcutaneous normal saline single dose

PF-06293620biological

Subcutaneous single dose 3 mg/kg

Placebobiological

Subcutaneous normal saline single dose

PF-06293620biological

Subcutaneous single dose 6 mg/kg

Placebobiological

Subcutaneous normal saline single dose

PF-06293620biological

Intravenous infusion single dose 1 mg/kg

Placebobiological

Intravenous infusion normal saline single dose

PF-06293620biological

Subcutaneous injection multiple dose 75 mg (Days 1, 29 and 57)

Placebobiological

Subcutaneous injection normal saline multiple dose (Days 1, 29 and 57)

PF-06293620biological

Subcutaneous injection multiple dose 150 mg (Days 1, 29 and 57)

Placebobiological

Subcutaneous injection normal saline multiple dose (Days 1, 29 and 57)

PF-06293620biological

Subcutaneous injection multiple dose 250 mg (Days 1, 29 and 57)

Placebobiological

Subcutaneous injection normal saline multiple dose (Days 1, 29 and 57)

PF-06293620biological

Subcutaneous injection multiple dose TBD mg (Days TBD)

Placebobiological

Subcutaneous injection normal saline multiple dose (Days TBD)