CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 660 enrolled
Drug / intervention
Genotype-guided dosing algorithm for warfarin +1 morebehavioral
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT02211326
NCT02211326N/ACompleted
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Pharmacogenetic Algorithm of Response to Warfarin During Initial Anticoagulation in Chinese Elderly Patients

The Third Xiangya Hospital of Central South University·interventional·Posted Aug 7, 2014·Updated Nov 6, 2017

In Brief

A clinical study evaluating Genotype-guided dosing algorithm for warfarin and Standard initiation dose for warfarin for Atrial Fibrillation and Deep Venous Thrombosis. Completed, enrolled 660 participants across 15 sites.

Detailed Summary

The purpose of this study is to determine whether the international pharmacogenetic algorithm is better than the standard initiation dosing and whether the two algorithms are suitable for Chinese elderly patients.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsAtrial Fibrillation, Deep Venous Thrombosis
CountriesChina
Collaborators--

Timeline

N/ACompletedFinished
201520162017201820192020202120222023202420252026
First PostedAug 7, 2014
Enrollment StartSep 1, 2014
Primary CompletionJan 16, 2017
Study CompletionMay 1, 2017
TodayJul 2, 2026
Enrollment to primary: 2.4 yearsPosted 11.9 years ago

Interventions

Genotype-guided dosing algorithm for warfarinbehavioral

Intervention：initial dosing of warfarin for the first 3 days of treatment will be determined by IWPC( International Warfarin Pharmacogenetics Consortium) algorithm (PG-1),a second dose adjustment will be made after 3 doses of warfarin using a dose revision algorithm (PG-2) that combined INR values,the dose will be adjusted depending on the measurements of INR values after 7 days.The overall follow-up period is 12 weeks.

Standard initiation dose for warfarinbehavioral

Intervention：initial dosing of warfarin for the first 3 days of treatment will be determined by standard initiation dose. Following this initiation dose of warfarin,the dose will be adjusted depending on the measurements of INR values after 3 days.The overall follow-up period is 12 weeks.