CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 20 enrolled
Drug / intervention
Single-fraction radiotherapy +1 moreradiation
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT02220491
NCT02220491N/ACompleted
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A Randomized Phase II Study of 20 Gy in 5 Fractions Whole Brain Radiotherapy Versus 15 Gy in 1 Fraction Volumetric Modulated Arc Therapy for One to Ten Brain Metastases

British Columbia Cancer Agency·interventional·Posted Aug 20, 2014·Updated May 20, 2020

In Brief

A clinical study evaluating Single-fraction radiotherapy and Whole-brain radiotherapy for Brain Metastases. Completed, enrolled 20 participants across 1 site.

Detailed Summary

Patients with brain metastases with expected life expectancy of 3-6 months are typically treated with radiotherapy to the whole brain giving a dose of 20 Gy over a 5 day period. This study will compare this with volumetric modulated arc therapy (VMAT) which is capable of delivering 15 Gy in one single session to identified disease within the brain but sparing the normal surrounding brain tissue. Primarily the study will assess whether it is possible to recruit sufficient patient numbers to a trial of this type. It will also compare effectiveness, side effects and quality of life between the two treatment methods.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsBrain Metastases
CountriesCanada
Collaborators--

Timeline

N/ACompletedFinished
201520162017201820192020202120222023202420252026
First PostedAug 20, 2014
Enrollment StartOct 1, 2014
Primary CompletionMay 18, 2020
TodayJul 2, 2026
Enrollment to primary: 5.6 yearsPosted 11.9 years ago

Interventions

Single-fraction radiotherapyradiation

Volumetric modulated arc therapy (VMAT) delivering 15 Gy in one fraction to brain metastases

Whole-brain radiotherapyradiation

Whole brain radiotherapy delivering 20 Gy in five fractions to brain metastases