CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 71 enrolled
Drug / intervention
Conducted AF Response (CAFR) +1 moredevice
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT02222818
NCT02222818N/ACompleted
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Cardiac Resynchronization Therapy Efficacy Enhancements

Medtronic Cardiac Rhythm and Heart Failure·interventional·Posted Aug 21, 2014·Updated Jan 6, 2017

In Brief

A clinical study evaluating Conducted AF Response (CAFR) and Conducted AF Response Plus (CAFRPlus) for Atrial Fibrillation. Completed, enrolled 71 participants across 19 sites in 7 countries.

Detailed Summary

The purpose of this study is to demonstrate that the amount of effective CRT (Cardiac Resynchronization Therapy) pacing during AF (atrial fibrillation) when CAFRPlus (Conducted AF Response Plus) is applied is not inferior to the amount of effective CRT pacing during AF when CAFR (Conducted AF Response) is applied.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsAtrial Fibrillation
CountriesHungary, Italy, Saudi Arabia, Slovakia, South Africa, United Kingdom, United States
Collaborators--

Timeline

N/ACompletedFinished
201520162017201820192020202120222023202420252026
First PostedAug 21, 2014
Enrollment StartOct 1, 2014
Primary CompletionJan 1, 2016
TodayJul 2, 2026
Enrollment to primary: 1.3 yearsPosted 11.9 years ago

Interventions

Conducted AF Response (CAFR)device

The CAFR algorithm is currently available in the Medtronic market-released devices and intended to promote delivery of CRT pacing during conducted AT/AF episodes.

Conducted AF Response Plus (CAFRPlus)device

The CAFRPlus algorithm is part of the CRTee feature set. This feature set has a diagnostic element that tracks the loss of effective CRT pacing that is occurring over time, both during normal sinus rhythm (NSR) and during AF. It also has an interventional element (i.e. CAFRPlus) that uses this evaluation of effective CRT pacing to adjust the pacing rate during AF to decrease loss of effective CRT pacing.