CI

At a glance

ClinicalIndex Comparison Record
Phase 3Completed· 695 enrolled
Drug / intervention
Exantide with Dapagliflozin +2 moredrug
Likely dose
Exantide with Dapagliflozin 2 mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT02229396
NCT02229396Phase 3Completed

A 28-week, Multicenter, Randomized, Double-Blind, Active-Controlled, Phase 3 Study With a 24-week Extension Phase Followed by a 52-week Extension Phase to Evaluate the Efficacy and Safety of Simultaneous Administration of Exenatide Once Weekly 2 mg and Dapagliflozin Once Daily 10 mg Compared to Exenatide Once Weekly 2 mg Alone and Dapagliflozin Once Daily 10 mg Alone in Patients With Type 2 Diabetes Who Have Inadequate Glycemic Control on Metformin

AstraZeneca·interventional·Posted Sep 1, 2014·Updated Dec 31, 2018

In Brief

A Phase 3 clinical trial evaluating Exantide with Dapagliflozin, Exentide, and 1 other intervention for Diabetes Mellitus. Completed, enrolled 695 participants across 133 sites in 6 countries.

Detailed Summary

Study D5553C0003 is a 28-week, randomized, double-blind, active-controlled, multicenter, Phase 3 efficacy and safety study with 24-week and 52-week extension phases of simultaneous administration of exenatide once weekly (EQW) 2 mg and dapagliflozin 10 mg once daily (QD) compared to EQW 2 mg alone and dapagliflozin 10 mg QD alone in patients with Type 2 diabetes who have inadequate glycemic control on metformin.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesHungary, Poland, Romania, Slovakia, South Africa, United States
Collaborators--

Timeline

Phase 3CompletedFinished
201520162017201820192020202120222023202420252026
First PostedSep 1, 2014
Enrollment StartSep 4, 2014
Primary CompletionApr 26, 2016
Study CompletionDec 28, 2017
TodayJul 2, 2026
Enrollment to primary: 1.6 yearsPosted 11.8 years ago

Interventions

Exantide with Dapagliflozindrug

2 mg weekly suspension injection and 10 mg Dapagliflozin

Exentidedrug

2 mg

Dapagliflozindrug

10 mg once daily Dapagliflozin