At a glance
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NCT02230839N/AActiveUpdate OverdueUpdated 10mo ago · Completion was 30mo agoMuscle Insulin Resistance In Aging
In Brief
A clinical study evaluating Exercise and Energy Restriction-Induced Weight Loss for Insulin Resistance and Sarcopenia. Active but no longer recruiting, targeting 200 participants across 1 site.
Signals
Detailed Summary
The purpose of this study is to provide information regarding potential factors underlying metabolic dysfunction, insulin resistance, and loss of muscle mass in aging muscle.
Study Details
Timeline
Interventions
Participants will complete a progressive 6-month exercise training program, 4-5 days per week, 45 min per session (180 min per week), consisting mostly of walking (both outside and on an indoor treadmill) but with the option to include stationary cycling, elliptical and rowing machines, similar to what we have utilized previously to elicit significant improvements in insulin sensitivity in both middle-age and older adults (52-55). Beginning at week 8, these subjects will also perform 2 non-consecutive resistance exercise sessions per week, 30 min per session, focused on major muscle groups using resistance machines (total days of exercise will still be 4 to 5).
The goal of the weight loss intervention will be to produce a weight loss of 10% body weight. A reduction of 500-1000 kcal/day - based on baseline weight -and low fat (\<30% of calories from fat) diet will be used as part of the weight loss intervention.