CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 58 enrolled
Drug / intervention
Carvedilol +2 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT02230891
NCT02230891Phase 2Completed

Biomarker Guided Therapies in Stage A/B Heart Failure

VA Office of Research and Development·interventional·Posted Sep 3, 2014·Updated Oct 21, 2022

In Brief

A Phase 2 clinical trial evaluating Carvedilol, Spironolactone, and 1 other intervention for Hypertension and 2 related conditions. Completed, enrolled 58 participants across 1 site.

Detailed Summary

Despite advances in cardiovascular care, the occurrence of heart failure (HF) is steadily increasing. The increase in HF rates poses enormous challenges, as once an individual becomes symptomatic or requires hospitalization with HF, the prognosis remains poor. Therefore, prevention of HF is essential. HF prevention is a critical issue as HF risk factors that include common medical conditions such as hypertension and diabetes are also increasing. However, not everyone with these risk factors develops HF. Using novel blood tests, the investigators propose to identify and treat subjects at higher HF risk to see if the investigators can stabilize or improve ultrasound measures known to be associated with HF risk. This study will enroll only Veterans.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesUnited States

Timeline

Phase 2CompletedFinished
201520162017201820192020202120222023202420252026
First PostedSep 3, 2014
Enrollment StartOct 1, 2014
Primary CompletionDec 15, 2020
TodayJul 2, 2026
Enrollment to primary: 6.2 yearsPosted 11.8 years ago

Interventions

Carvediloldrug

Carvedilol is a non selective beta blocker

Spironolactonedrug

Spironolactone is an aldosterone antagonist and can lower blood pressure/ is used in heart failure

Usual careother

standard care as per primary care provider