CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 39 enrolled
Drug / intervention
Permeability measurement +2 moreother
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT02246647
NCT02246647N/ACompleted
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Biomarkers for Intestinal Permeability in Patients With Functional Lower Gastrointestinal Disorders Associated With Constipation.

Mayo Clinic·observational·Posted Sep 23, 2014·Updated Aug 21, 2019

In Brief

An observational study evaluating Permeability measurement, Esophagogastroduodenoscopy, and 1 other intervention for Intestinal Diseases and 2 related conditions. Completed, enrolled 39 participants across 1 site.

Detailed Summary

Our overall objective with this study is firstly to provide a comprehensive assessment of intestinal permeability, mucosal barrier function using existing biomarkers and secondly to explore novel biomarkers for measuring intestinal permeability in patients with constipation predominant Irritable Bowel Syndrome (IBS-C).

Study Details

Study Typeobservational
Allocation--
Masking--
Primary Purpose--
ConditionsIntestinal Diseases, Irritable Bowel Syndrome, Constipation
CountriesUnited States
CollaboratorsTakeda Pharmaceuticals International, Inc.

Timeline

N/ACompletedFinished
201520162017201820192020202120222023202420252026
First PostedSep 23, 2014
Enrollment StartSep 1, 2014
Primary CompletionDec 8, 2016
TodayJul 2, 2026
Enrollment to primary: 2.3 yearsPosted 11.8 years ago

Interventions

Permeability measurementother

Saccharide excretion was compared between IBS-C and healthy volunteers

Esophagogastroduodenoscopyprocedure

Duodenal biopsies were collected from IBS-C and healthy volunteers

Flexible sigmoidoscopyprocedure

Colonic biopsies were collected from IBS-C and healthy volunteers