CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 44 enrolled
Drug / intervention
Chlorhexidine +1 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT02252588
NCT02252588Phase 2Completed
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The Effect of Chlorhexidine on the Oral and Lung Microbiota in Chronic Obstructive

University of Minnesota·interventional·Posted Sep 30, 2014·Updated Dec 29, 2020

In Brief

A Phase 2 clinical trial evaluating Chlorhexidine and Placebo for Chronic Obstructive Pulmonary Disease. Completed, enrolled 44 participants across 1 site.

Detailed Summary

Determine the effect of twice-daily chlorhexidine oral rinse on oral and lung microbiota biomass in subjects with chronic obstructive pulmonary disease (COPD) with chronic bronchitis. Our primary outcome will be to compare the microbiota biomass (number of bacteria as measured by 16S rRNA copy number) of induced sputum and the oral cavity before and after 8 weeks of twice-daily chlorhexidine oral rinse (n=25) compared to controls (n=25) using qPCR and next-generation sequencing of the bacterial 16S rRNA gene comparing total bacterial biomass

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsChronic Obstructive Pulmonary Disease
CountriesUnited States
CollaboratorsVeterans Medical Research Foundation, Flight Attendant Medical Research Institute

Timeline

Phase 2CompletedFinished
201520162017201820192020202120222023202420252026
First PostedSep 30, 2014
Enrollment StartSep 1, 2014
Primary CompletionDec 15, 2019
Study CompletionJan 1, 2020
TodayJul 2, 2026
Enrollment to primary: 5.3 yearsPosted 11.8 years ago

Interventions

Chlorhexidinedrug

Oral Rinse

Placeboother

Oral Rinse