CI

At a glance

ClinicalIndex Comparison Record
Phase 2Active· 236 enrolled
Drug / intervention
Ixazomib +2 morebiological
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT02253316
NCT02253316Phase 2Active

A Phase II Study of IRD (Ixazomib, Lenalidomide, & Dexamethasone) for Consolidation Therapy Post Autologous Stem Cell Transplantation Followed by Maintenance Ixazomib or Lenalidomide for Multiple Myeloma

Washington University School of Medicine·interventional·Posted Oct 1, 2014·Updated Nov 10, 2025

In Brief

A Phase 2 clinical trial evaluating Ixazomib, Lenalidomide, and 1 other intervention for Multiple Myeloma. Active but no longer recruiting, targeting 236 participants across 10 sites.

Detailed Summary

The purpose of this research study is to evaluate a treatment regimen called IRD which will be given to participants after their stem cell transplant in an effort to help prolong the amount of time the participants are disease-free after transplant. IRD is a three-drug regimen consisting of ixazomib, lenalidomide (also called Revlimid), and dexamethasone. After 4 cycles of IRD, the participants will be randomized to receive maintenance therapy either with ixazomib or lenalidomide.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesUnited States

Timeline

Phase 2Active
201520162017201820192020202120222023202420252026
First PostedOct 1, 2014
Enrollment StartJan 20, 2015
Primary CompletionFeb 5, 2020
Study CompletionAug 31, 2026
TodayJul 2, 2026
Enrollment to primary: 5.0 yearsPosted 11.8 years ago

Interventions

Ixazomibbiological

Lenalidomidedrug

Dexamethasonedrug