At a glance
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Remediation of Impaired Self-Regulation in Patients With Mild TBI
In Brief
A Early Phase 1 clinical trial evaluating Tolcapone and Placebo for Mild Traumatic Brain Injury. Completed, enrolled 55 participants across 1 site.
Detailed Summary
The ability to regulate impulses enables us to plan for the future, to maintain focus in the face of distractions (i.e. to encode memories), and to manage emotions. This self regulation can be compromised in individuals who have a history of mild traumatic brain injury and co-occurring disorders. In this study the investigators are using functional MRI scanning to understand how memory and self regulation are expressed in the brains of people with a history of mild traumatic brain injury. The investigators are also testing whether the medication tolcapone may improve memory and self regulation.
Study Details
Timeline
Interventions
COMT Inhibitor
A pill that contains no active ingredient