CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 105 enrolled
Drug / intervention
MEK162drug
Likely dose
MEK162 15 mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT02285439
NCT02285439Phase 2Completed
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Phase I-II Study of MEK 162 for Children With Low-Grade Gliomas and Other Ras/Raf/ERK Pathway Activated Tumors

Children's Hospital Los Angeles·interventional·Posted Nov 7, 2014·Updated Oct 7, 2025

In Brief

A Phase 2 clinical trial evaluating MEK162 for Low-Grade Gliomas and 2 related conditions. Completed, enrolled 105 participants across 15 sites.

Detailed Summary

The goal of this clinical trial is to study the drug MEK162 in children with a brain tumor call low-grade glioma, as well as in children with other tumors in which a specific growth signal is abnormally turned on. The main questions it aims to answer are: What is the correct dose of MEK162 in children? What are the side effects of MEK162 in children? Is MEK162 effective in children with low-grade glioma? Participants on the study receive MEK162 by mouth twice daily for up to 2 years.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsLow-Grade Gliomas, Malignant Neoplasms, Brain, Soft Tissue Neoplasms
CountriesUnited States
CollaboratorsDana-Farber Cancer Institute

Timeline

Phase 2CompletedFinished
201520162017201820192020202120222023202420252026
First PostedNov 7, 2014
Enrollment StartMay 4, 2016
Primary CompletionNov 2, 2022
Study CompletionAug 1, 2025
TodayJul 2, 2026
Enrollment to primary: 6.5 yearsPosted 11.7 years ago

Interventions

MEK162drug

• MEK162 is currently supplied as film-coated tablets in dose strength of 15 mg. The film-coated tablets consist of MEK162 drug substance, lactose monohydrate, microcrystalline cellulose, colloidal silicon dioxide, croscarmellose sodium, magnesium stearate, and a commercial film coating. The original tablets are yellow to dark yellow capsule-shaped