At a glance
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Methadone in Ambulatory Surgery
In Brief
A clinical study evaluating methadone and Control (Intra-operative administration of opioids, other than methadone) for Post-operative Pain and Anesthesia. Completed, enrolled 60 participants across 1 site.
Detailed Summary
The μ-opioid receptor agonist methadone is frequently used in adult anesthesia and adult pain therapy. Methadone has an extremely long half-life, which confers therapeutic advantage by providing more stable plasma concentrations and long-lasting pain relief. Methadone perioperative pharmacokinetics and effectiveness in perioperative pain relief in inpatients is well characterized. There is, however, no information on methadone use in an ambulatory surgery setting and outpatient procedures. This pilot investigation will determine effectiveness of intraoperative methadone in reducing postoperative opioid consumption and providing improved pain relief in patients undergoing moderately painful, ambulatory surgical procedures.
Study Details
Timeline
Interventions
Escalating dose of methadone up to .3mg/kg.
Intra-operative administration of opioids, other than methadone