CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 42 enrolled
Drug / intervention
Vorinostat +2 moredrug
Likely dose
Vorinostat 400mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT02316340
NCT02316340Phase 2Completed

Modulation of Autophagy: A Clinical Study of Vorinostat Plus Hydroxychloroquine Versus Regorafenib in Refractory Metastatic Colorectal Cancer (mCRC) Patients (CTMS# 14-2015)

The University of Texas Health Science Center at San Antonio·interventional·Posted Dec 12, 2014·Updated Jan 5, 2024

In Brief

A Phase 2 clinical trial evaluating Vorinostat, Hydroxychloroquine, and 1 other intervention for Colorectal Cancer. Completed, enrolled 42 participants across 1 site.

Detailed Summary

This will be a randomized phase II clinical trial of patients with histologic documentation of metastatic colorectal cancer, who have received local and currently approved standard therapies, excluding RGF.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesUnited States
Collaborators--

Timeline

Phase 2CompletedFinished
201520162017201820192020202120222023202420252026
First PostedDec 12, 2014
Enrollment StartFeb 11, 2015
Primary CompletionMar 7, 2018
Study CompletionApr 16, 2018
TodayJul 2, 2026
Enrollment to primary: 3.1 yearsPosted 11.6 years ago

Interventions

Vorinostatdrug

400mg by mouth daily

Hydroxychloroquinedrug

600mg by mouth daily

Regorafenibdrug

160 mg by mouth daily