At a glance
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Spinal Epidural Electrode Array to Facilitate Standing and Stepping After Spinal Cord Injury
In Brief
A clinical study evaluating Standing and Stepping with spinal cord Epidural Stimulation for Spinal Cord Injury. Completed, enrolled 8 participants across 1 site.
Detailed Summary
The overall aim is to assess whether task specific locomotor training and spinal cord electrical stimulation (SCES) can induce neural reorganization of the functionally isolated human spinal cord to improve standing and stepping in individuals with functionally complete SCI. The investigators propose that locomotor training will result in generation of more effective standing and stepping efferent patterns by restoring phase dependent modulation of reflexes and reciprocal inhibition, reducing clonus and mediating interlimb coordination. The investigators propose that the SCES will optimize the physiological state of the spinal cord interneuronal circuitry compromised by compensating for loss of supraspinal input for the retraining of these tasks.
Study Details
Timeline
Interventions
Standing and Stepping with support from trainers as needed, overground or in a harness with body weight support on a treadmill. Epidural stimulation with specific configurations will be administered to generate standing and stepping.