At a glance
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Detection and Clinical Significance of Circulating Cancer Cells in Patient Undergoing Radical Cystectomy
In Brief
An observational study evaluating Detection of circulating tumor cells in blood samples for Bladder Cancer and Circulating Tumor Cells. Completed, enrolled 59 participants across 1 site.
Detailed Summary
Very few factors may be identified as prognostic for patients with bladder cancer undergoing radical cystectomy. Recently, detection of circulating tumor cells has shown to be very promising in anticipating both the likelyhood of distant metastases and survival in patients with breast cancer, melanoma, prostate cancer and other malignancies. In the present study we both tested the detection rate of circulating tumor cells using a PCR based methodology in the peripheral blood of patients undergoing radical cystectomy, and we further correlated our results with their clinical outcome.
Study Details
Timeline
Interventions
Ficoll based isolation of mononuclear cells from the peripheral blood of patients undergoing radical cystectomy, nucleic acids extraction and, finally, PCR based detection of sequences specific to cytokeratins.